The president of IIDR, Dr. Yoshino, obtained a degree of Ph.D. from Tohoku University, Sendai, Japan and had research experiences in UK (Department of Rheumatology, School of Medicine, University of Birmingham), in USA (Department of Pharmacology, Medical School, New York University; Neurologic Disease Center, Brigham and Women’s Hospital, Harvard Medical School), in Germany (Department of Rheumatology and Clinical Immunology, Max-Planck Institute), and in Japan (Department of Microbiology, Saga Medial School). In 2000, Dr. Yoshino was appointed as a professor of pharmacology at Kobe Pharmaceutical University. Dr. Yoshino founded the Institute of Immune Disease Regulation in 2017. His research interests include establishment of antigen-specific regulation of autoimmune and allergic diseases, based on clarification of the pathogenesis of the diseases. Dr. Yoshino published more than 200 papers in international journals.
スタッフ
IIDR代表（所長）である吉野 伸は東北大学薬学部を卒業後、同大学大学院薬学研究科にて修士および博士（薬学）の学位を取得した。その後12年間の英国（バーミンガム大学医学部リウマチ学）、米国（ニューヨーク大学医学部薬理学、ハーバード大学医学部ブリガム＆ウィメンズ病院神経疾患センター）、独国（マックス・プランク研究所リウマチ・臨床免疫学）などでの海外研究生活を経て、佐賀医科大学医学部微生物学（現佐賀大学医学部）および神戸薬科大学薬学部薬理学（教授）にて研究および教育に従事し、2017年にIIDRを設立した。専門は「関節リウマチを主とする自己免疫病およびスギ花粉症、喘息などのアレルギーの発症機序に基づく抗原（疾患）特異的原因療法の確立」であり、これまで国際学術雑誌に掲載された論文数は200編を超える。
Original papers (examples)：原著論文（例）
Yoshino, S., Mizutani, N.: Intranasal exposure to monoclonal antibody Fab fragments to Japanese cedar pollen Cry j1 suppresses Japanese cedar pollen-induced allergic rhinitis. Br. J. Pharmacol., 173: 1629-1638, 2016. Impact factor (IF): 9.473
Yoshino, S., Mizutani, N., Matsuoka, D., Sae-Wong, C.: Intratracheal exposure to Fab fragments of an allergen-specific monoclonal antibody regulates asthmatic responses in mice. Immunol., 141:617-627, 2014. IF: 7.215
Yoshino, S., Sasahara, M., Hutamekalin, P., Yamaki, K., Mizutani, N., Kuramato, H.: Suppression of antibody-mediated arthritis in mice by Fab fragments of the mediating antibodies. Br. J. Pharmacol., 161:1351-1360, 2010. IF: 9.473
Yoshino, S., Yamaki, K., Li, X., Sai, T., Yanagisawa, R., Takano, H., Taneda, S., Hayashi, H., Mori, Y.: Prenatal exposure to bisphenol A up-regulates immune responses, including T helper 1 and T helper 2 responses, in mice. Immunol., 112:489-495, 2004. IF: 7.215
Yoshino, S., Yamaki, K., Yanagisawa, R., Takano, H., Hayashi, H., Mori, Y.: Effects of bisphenol A on antigen-specific antibody production, proliferative responses of lymphoid cells, and Th1 and Th2 immune responses in mice. Br. J. Pharmacol., 137:1271-1276, 2003. IF: 9.473
Yoshino, S., Ohsawa, M.: The role of lipopolysaccharide injected systemically in the reactivation of collagen-induced arthritis in mice. Br. J. Pharmacol., 129:1309-1314, 2000. IF: 9.473
Yoshino, S., Murata, Y, Ohsawa, M.: Successful induction of adjuvant arthritis in mice by treatment with a monoclonal antibody to interleukin-4. J. Immunol., 161:6904-6908, 1998. IF: 5.430
Yoshino, S., Ohsawa, M., Sagai, M.: Diesel exhaust particles block induction of oral tolerance in mice. J. Pharmacol. Exp. Ther., 287:679-683, 1998. IF: 4.404
Yoshino, S., Quattrocchi, E., Weiner, H.L.: Suppression of antigen-induced arthritis in Lewis rats by oral administration of type II collagen. Arthritis Rheum. 38: 1092-1096, 1995. IF: 13.300
Yoshino, S., Cleland, G.L., Mayrhofer, G.:, Brown, R.R., Schwab, J.H.: Prevention of chronic erosive streptococcal cell wall-induced arthrtis in rats by treatment with a monoclonal antibody against the alpha/beta T cell antigen receptor. J. Immunol. 146: 4187-4189, 1991. IF: 5.430
Yoshino, S., Cleland , G.L., Mayrhofer, G.: Treatment of collagen-induced arthritis in rats with a monoclonal antibody against the alpha/beta T cell antigen receptor. Arthritis Rheum. 34: 1039-1047, 1991. IF: 13.300
Yoshino, S., Cleland, G.L.: Depletion of alpha/beta T cells by a monoclonal antibody against the alpha/beta T cell receptor suppresses established adjuvant arthritris, but not established collagen-induced arthritis in rats. J. Exp. Med. 175: 907-915, 1992. IF: 17.579
Yoshino, S., Schlipkoter, E., Kinne, R., Hunig, T., Emmrich, F.: Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody against the alpha/beta T cell antigen receptor. Eur. J. Immunol. 20: 2805-2808, 1990． IF: 6.688
Yoshino, S., Cromartie, W.J., Schwab, J.H.: Inflammation induced by bacterial cell wall fragments in the rat air pouch: comparison of rat strains and measurement of arachidonic acid metabolites. Amer. J. Pathol. 121: 327-336, 1985. IF: 5.770
Yoshino, S., Blake, D.R., Hewitt, S., Morris, C., Bacon, P.A.: Effect of blood on the activity and persistence of antigen-induced inflammation in the rat air pouch. Ann. Rheum. Dis. 44:490-495, 1985. IF: 27.400
